There is a great variety, of elements acting as inhibitors or accelerators on intestinal motility. Especially complications such as depletion of intestinal movement or paralytic condition of the intestine are often produced during the post-operative period, and it is often difficult to determine the etiology. There have been many studies recently reported on the changes of intestinal motility by the alteration of sodium, chloride, potassium or carbon dioxide tension. The author has made a study to determine the changes of intestinal motility due to changes of pH.
For in vivo experimental study dogs were used with air balloons placed in the intestine through various fistulas and intestinal movement was registered by tambour and recorded on a kymograph. For in vitro study isolated segmonts of small intestine of rabbits were used and connected to Trendelenberg´s apparatus which was modified by the author, and the curves of the movements in Tyrode´s solution and the movements by the changes of PH due to adding of acid or alkali reagents in the solution were observed. The reagents used were as follows: Lactic acid, Acetic acid, Sodium phosphate,.. 1/10 N.:- Hydrochloric acid. 1/10 N. Oxalic acid, 1/10 N. Boric acid,. 1/10 N. Phosphoric acid,. Sodium acetate, Sodium bicarbonate, 1/10 N. Sodium hydroxide and 1/10 N. Potassium hydro
After the observation of the changes of motility by the changes of pH, the reaction of drugs acting on the autonomic system was observed.
An experiment has also been made to observe intestinal motility influenced by anesthetics, to determine how much the intestinal ´motility depressed under various anesthetics and as to whether paralytic ileus occurs by it.
The.´ result of the study is as follows
1) As a result of about 130 undertakings in this study it was observed that increasing pH resulted in propulsive and accelerated reaction of intestinal tonus and motility in both in vitro and in vivo experiments, while intestinal tonus and motility became relaxed and inhibited by various reagents which produce a lowering of the pH.
2) There was no response to parasympathomimetic drugs in acid media, only in either neutral or alkaline media.
3) All anesthetics inhibit intestinal motility with the exception of spinal anesthesia.. The mildest inhibition was seen when nitrous oxide was used, and the degree of inhibition was increased in the order of Sodium pentothal; Cycloprepane and Ether. Intestinal motility returned quickly to normal with mild alkalosis due to hyperventration during the reacting time.
4) Paralytic ileus can be induced in mild acidosis. When paralytic ileus is proved by the levels of serum of plasmbicarbonate, carbon dioxide content and combining power, the treatment can be solved simply.
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